Alex Zanardi, a former Formula 1 racing driver, has lost both his legs in a crash. Zanardi was leaving the pit lane when he spun and was hit by Alex Tagliani coming down Start/Finish at 200mph.
The accident happened at the Lautzisring in Germany. Zanardi was driving in ChampCars at the time, and following his accident was taken to hospital in Berlin, where both his legs were amputated above the knee. See link for more information.